BIOSTATISTICS:

Basically biostatistics is used to measure statistics of Public health, nutrition and environmental health, including epidemiology, Design and analysis of clinical trials in medicine, Genomics, population genetics, and statistical genetics in populations in order to link variation in genotype with a variation in phenotype. It is also been used in agriculture to improve quality of crops and animals. Large number of biomedical research centers, use this to searching for gene alleles that may cause or influence predisposition to diseases in human genetics, Biological sequence analysis, Statistical methods are beginning to be integrated into medical informatics, public health etc. For instance biostatistics can be used to:

• Spatial and time analysis of the impact of antibiotic and vaccine population exposure on the infection/infectious risk in the community. Intend to quantify the impact of the decrease of the antibiotic use as well as the increase of the conjugated vaccine vaccination on Streptococcus pneumonia antibiotic resistance.

• Epidemiological analysis of the selective impact of antibiotic use on bacterial resistance in context of exposure with multiple antibiotic classes and multi resistance, taking into account the environmental exposure to bacterial resistance and the influence of the dosage of antibiotic in function of mechanisms of resistance.

• Mathematical modification of population dynamics of bacterial colonization and transmission in interaction with population exposure with drugs. A central point of interest in this mathematical project whether widespread antibiotic conjugate vaccines use in the human population could result in the emergence of non-vaccine resistant stereotypes and the control of bacterial resistance taking into account multi resistance and multi antibiotic exposure.